Journal of North Khorasan

Abstract Background & Objectives: lipids play (or have) a major role in many critical functions of body but their growing up can increase the risk of cardiovascular diseases. This study investigates the hyperlipidemia incidence and its relationship with nutritional pattern, life style and anthropometric indices in North Khorasan Province, Iran. Materials & Methods: it is a cross-sectional study, which was performed on the teachers of North Khorasan province since 2009 to 2010. Demographic features, nutritional patterns, life style and Anthropometric indices were measured and recorded by using of standard scales. An 8mL fasting blood sample was collected after 12h fasting. Blood samples were centrifuged at 3000 g for 10 minutes and the serum aliquots was separated and stored at -20 oC. The GPO-PAP and GHOD-PAP methods (Zist-chimi company kits) were usedin order to determine the cholesterol and triglyceride concentration respectively. LDL-c and HDL-c concentrations were determined using Biosystem company kits. Findings: Total of 11704 (99.9%) volunteers among the 11713 teachers (5730 males and 5983 females, age 50.64±6.62 years), participated in this study. The mean concentration of cholesterol, triglyceride, HDL-c and LDL-c in men were 196.4± 42.7, 164.2±96.4, 46.8±1.3 and 107.7±3.9 and in women was 190.9±39.8, 132.1±71, 50±1.2 and 110.9±3.4 respectively. The hypercholesterolemia and hypertriglyceridemia prevalence and increased LDL-c levelin the age group 20-45 yearswas significantly more than age group 45-70 years. Hypercholesterolemia was directly associated with the male gender, central obesity and BMI (body mass index) and smoking, and inversely with the age group. Data was shown that the serum HDL-c level in females was lower than males and the serum LDL-c concentration in males was lower than females. Conclusion: This study shows high prevalence of hypercholesterolemia, hypertriglyceridemia, serum increased LDL-c level, low physical activity in the age group 20-45 years. It seems that the lower age group expose to the heart disease more than age group 45-70 years