Journal of North Khorasan

Background & Objectives: In the world rhizome of ginger is used as a food flavoring and in the treatment of many diseases including diabetes. Considering the prevalence of diabetes during pregnancy and cost of chemical drugs that is used in treating the disorder, especially during pregnancy and lactation and their side effects on children, this study aimed to investigate the effect of neonatal and perinatal extract of ginger on insulin levels and enzymes ALT, AST, ALP in offspring of adult rats. Material & Methods: This experimental study was conducted on 72 adult female rats. The rats were divided into 9 groups (N=8)including perinatal , neonatal control and 6 experimental groups receiving doses of 50,100 mg / kg 200 mg / kg alcoholic extract of ginger(orally). At the end of the experiments, blood was collected from heart, and the isolated serum from samples was analyzed for the insulin levels and ALT, AST, ALP enzymes. Data were analyzed by using ANOVA and Duncan tests. Results: The results showed that ginger rhizome extract causes significant increase in levels of insulin and significant dose-dependent decrease in ALT, AST, ALP enzymes on male and female offspring. Conclusion: Ginger with compounds, Jinjerols, Sezkuinterpens, selenium, flavonoids and antioxidants and anti-inflammatory stimuli, serotonin secretion and reduce blood glucose has significant effects on insulin levels and enzymes ALT, AST, ALP.