Journal of North Khorasan

Abstract Background & Objectives: Nowadays it is very desirable to investigate and discover new antibacterial and anticancer agents from natural products and medicinal plants. In this regard, the current study is conducted in order to explore the antibacterial and antioxidant properties of a rare plant named Uvaria grandiflora Roxb. Material & Methods: The antibacterial disc diffusion method, the DPPH radical scavenging test and the preliminary phytochemical screening were performed for six different extracts obtained by hexane, chloroform and ethanol. Results: Data exhibited the stem bark and leaves ethanolic extract of the plant, have high amounts of flavonoids and poly-phenols and therefore they have strongly inhibited Staphylococcus aureus and Bacillus cereus growth at the concentration of 2mg/disc. These samples illustrated the highest radical scavenging activity with the percentages of 95.32% and 86.38% at the concentration of 100µg/ml, respectively. Conclusion: Following the results, it was concluded that the flavonoids and poly-phenols play crucial roles in the properties of Uvaria grandiflora Roxb., thus more investigations and isolations are recommended