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URL: http://journal.nkums.ac.ir/article-1-633-en.html
Background & Objectives: Her2/neu is a biomarker which is overexpressed in a subset of breast cancer patients who are eligible to receive treatment. Her-2 gene amplification analyzed by MLPA that is a new method to detect Her-2 status in clinical practice.
Material and Methods: 60 patients, who were operated in Afzalipour Hospital of Kerman, were enrolled in this cross-sectional study. The pathologic specimens were evaluated by MLPA method for detecting HER2 overexpression. The data were analyzed by SPSS21 software and CHI SQUARE test.
Results: Correlation between HER2 overexpression and lymph node involvement was remarkable (P value=0.0). HER2 over overexpression and size of tumor had obvious relation (P value=0.036). All the patients with HER2 overexpression were stage3 of malignancy (P value=0.0).
Conclusion: According to the results of this study it can be concluded MLPA method is a suitable method for detecting overexpression of HER2 in patients with breast cancer.
Keywords: Breast Cancer, HER2/neu Overexpression, MLPA
Received: 2015/12/26 | Accepted: 2015/12/26 | Published: 2015/12/26
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