Journal of North Khorasan

Background & Objectives: Stroke is the second leading cause of death worldwide and is one of the main causes of long-term disabilities. The aim of this study was to assess the effect of Melatonin and Progesterone on stroke complications.

Materials and Methods: Sixty four male wistar rats were enrolled in the present study. Common carotid arteries were closed for 20 minutes. Then the animals were treated with 8 mg/kg Progesterone and10 mg/kg Melatonin. Moriss water maze test was done after 2 weeks. Then the animals were sacrificed and histological examination was performed.

Results: The results showed that Progesterone and Melatonin increased the number of pyramidal cells and improved spatial memory in comparison with the ischemic and solvent groups (p<0.05). There wasn’t any significant difference between treatment groups (p>0.05)

Conclusion: It seems that the Progesterone and  Melatonin usage have beneficial effects on improving spatial memory and behavioral functions after stroke.