Background and Objectives: Epididymoorchitis is relatively common disease that in addition to Neisseria gonorrhea, Chlamydia trachomatis and Escherichia coli, Brucella must be considered as an etiologic factor especially in endemic area. The aim of current study is comparison of epidemiologic and clinical presentation of brucella epididymoorchitis with nonbrucella epididymoorchitis in Hamadan Province. Materials and Methods: During this cross sectional study, 115 epididymoorchitis patients that were treated inpatient or outpatient, evaluated as 2 groups either brucella epididymoorchitis (group1= 38) or nonbrucella epididymoorchitis (group 2 = 77) during 6 years. Results: There were not seen statistical differences in mean age, marital status, side of involvement, occupational exposure, and the illness occurrence season between the groups. Brucella epididymoorchitis were seen more in rural living patients and nonbrucella epididymoorchitis in town living cases (p=0.02). Conclusion: In brucellosis endemic areas such as Iran, urologists should be consider the likelihood of brucella epididymoorchitis especially in complex, recurrent, treatment resistant and occupational exposure patients with careful history, physical examination and laboratory evaluation.
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