Volume 18, Issue 3 (Autumn 2026)
nkums 2026, 18(3): 36-42 |
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Ethics code: IR.MUMS.IRH.REC.1402.186
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Tabrizi K, Baradaran Rahimi V, Tayyebi M, Zandi Z. Impact of Catheter Ablation of Premature Ventricular Contractions on NYHA Functional Class and Left Ventricular Function. nkums 2026; 18 (3) :36-42
URL: http://journal.nkums.ac.ir/article-1-3425-en.html
URL: http://journal.nkums.ac.ir/article-1-3425-en.html
1- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Patient Safety Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,zandiz@mums.ac.ir
2- Patient Safety Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (58 Views)
Introduction: Premature ventricular contractions (PVCs) are a prevalent ventricular arrhythmia. Although PVCs are often benign, a high PVC burden can lead to PVC-induced cardiomyopathy (PIC), which is characterized by impaired left ventricular systolic function. Catheter ablation has emerged as an effective intervention for patients with symptomatic, drug-refractory PVCs. This study aimed to evaluate the impact of successful PVC ablation on functional status, left ventricular ejection fraction (LVEF), and health-related quality of life (QoL).
Methods: This retrospective analysis included 50 consecutive patients who underwent successful PVC ablation at a tertiary referral center (Imam Reza Hospital, Mashhad, Iran) between 2020 and 2022. Demographic characteristics, New York Heart Association (NYHA) functional class, LVEF (assessed via biplane Simpson's method), symptom profile, and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores were evaluated at baseline and at a six-month follow-up.
Results: The mean age of participants was 46.5 ± 7.8 years, of whom 60% were female. At six months post-ablation, the NYHA functional class demonstrated significant improvement (1.6 ± 0.63 vs. 0.12 ± 0.33; P = 0.002). The proportion of patients classified as NYHA class I increased from 54% to 92%. Mean LVEF increased from 47.7 ± 10.5% to 52.2 ± 8.9% (P < 0.05). Concurrently, MLHFQ scores indicated significant improvements across physical, emotional, and social domains.
Conclusion: Successful catheter ablation of PVCs is associated with marked improvements in left ventricular systolic function, functional capacity, and patient-reported quality of life. Early referral for ablation should be considered in patients with a high PVC burden or evidence of left ventricular dysfunction to avert irreversible myocardial remodeling.
Methods: This retrospective analysis included 50 consecutive patients who underwent successful PVC ablation at a tertiary referral center (Imam Reza Hospital, Mashhad, Iran) between 2020 and 2022. Demographic characteristics, New York Heart Association (NYHA) functional class, LVEF (assessed via biplane Simpson's method), symptom profile, and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores were evaluated at baseline and at a six-month follow-up.
Results: The mean age of participants was 46.5 ± 7.8 years, of whom 60% were female. At six months post-ablation, the NYHA functional class demonstrated significant improvement (1.6 ± 0.63 vs. 0.12 ± 0.33; P = 0.002). The proportion of patients classified as NYHA class I increased from 54% to 92%. Mean LVEF increased from 47.7 ± 10.5% to 52.2 ± 8.9% (P < 0.05). Concurrently, MLHFQ scores indicated significant improvements across physical, emotional, and social domains.
Conclusion: Successful catheter ablation of PVCs is associated with marked improvements in left ventricular systolic function, functional capacity, and patient-reported quality of life. Early referral for ablation should be considered in patients with a high PVC burden or evidence of left ventricular dysfunction to avert irreversible myocardial remodeling.
Keywords: Catheter ablation, Ejection fraction, NYHA class, Premature ventricular contractions, Quality of life
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2026/04/26 | Accepted: 2026/07/12 | Published: 2026/09/29
Received: 2026/04/26 | Accepted: 2026/07/12 | Published: 2026/09/29
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