Volume 18, Issue 3 (Autumn 2026)
nkums 2026, 18(3): 52-59 |
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Ethics code: IR.NKUMS.REC.1399.100
Clinical trials code: IRCT20210112050013N1
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Amiri Z, Rasekhi J, Mohammadi A, Sharifian E, Rameshrad M. Evaluation of the Effect of Probiotics on Salivary PH and Flow Rate in Healthy Individuals. nkums 2026; 18 (3) :52-59
URL: http://journal.nkums.ac.ir/article-1-3427-en.html
URL: http://journal.nkums.ac.ir/article-1-3427-en.html
1- Dental Student, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- Assistant Professor, Department of Oral and Maxillofacial Diseases, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- MSc in Phytochemistry, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- MSc in Epidemiology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Assistant Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran ,mrameshrad@gmail.com
2- Assistant Professor, Department of Oral and Maxillofacial Diseases, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- MSc in Phytochemistry, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- MSc in Epidemiology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Assistant Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran ,
Abstract: (63 Views)
Introduction: Salivary pH is a key indicator of the onset of dental caries, which can be controlled to prevent tooth demineralization. Furthermore, reduced salivary flow rate can adversely affect oral health. Probiotics are beneficial bacteria that, when consumed in sufficient quantities, exert positive effects on human health. This clinical trial was designed and conducted to investigate the efficacy of probiotic consumption on salivary pH and flow rate.
Methods: In this clinical trial, 59 healthy individuals were randomly assigned to either a probiotic or a placebo group. Participants consumed either probiotic or placebo tablets for one month. Salivary samples were collected at baseline, immediately after the one-month intervention period, and after a one-month follow-up period. Salivary flow rate was determined by weight, and pH levels were measured accordingly. Data were analyzed using the chi-square, Mann-Whitney U, Friedman, Wilcoxon, independent t-tests, and multiple repeated measures ANOVA via SPSS software (version 26).
Results: Comparison of salivary pH between the two groups showed a significant increase in pH in the probiotic group, compared to the placebo group, but only during the follow-up period. This finding was statistically marginal (P = 0.08). Regarding salivary flow rate, participants in the placebo group exhibited a higher flow rate than those in the probiotic group following the intervention.
Conclusion: According to the results of this study, probiotic consumption may increase salivary pH in the long term, even after the discontinuation of the intervention. However, it does not appear to be associated with an increase in salivary flow rate.
Methods: In this clinical trial, 59 healthy individuals were randomly assigned to either a probiotic or a placebo group. Participants consumed either probiotic or placebo tablets for one month. Salivary samples were collected at baseline, immediately after the one-month intervention period, and after a one-month follow-up period. Salivary flow rate was determined by weight, and pH levels were measured accordingly. Data were analyzed using the chi-square, Mann-Whitney U, Friedman, Wilcoxon, independent t-tests, and multiple repeated measures ANOVA via SPSS software (version 26).
Results: Comparison of salivary pH between the two groups showed a significant increase in pH in the probiotic group, compared to the placebo group, but only during the follow-up period. This finding was statistically marginal (P = 0.08). Regarding salivary flow rate, participants in the placebo group exhibited a higher flow rate than those in the probiotic group following the intervention.
Conclusion: According to the results of this study, probiotic consumption may increase salivary pH in the long term, even after the discontinuation of the intervention. However, it does not appear to be associated with an increase in salivary flow rate.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2026/02/16 | Accepted: 2026/05/26 | Published: 2026/09/29
Received: 2026/02/16 | Accepted: 2026/05/26 | Published: 2026/09/29
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