Volume 13, Issue 3 (12-2021)
2021, 13(3): 102-112 |
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Naseri P, Alihemati A, Taifi Nasrabadi H, Rasta S H. Compared the Effect of Red and Infrared Low-Level Lasers on Folliculogenesis Cycle with the Effect of Clomiphene Drug in Rat’s Ovarian Tissue. North Khorasan University of Medical Sciences 2021; 13 (3) :102-112
URL: http://journal.nkums.ac.ir/article-1-2441-en.html
URL: http://journal.nkums.ac.ir/article-1-2441-en.html
1- Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3- School of Medical Sciences, University of Aberdeen, Aberdeen, UK ,mph586@gmail.com
2- Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3- School of Medical Sciences, University of Aberdeen, Aberdeen, UK ,
Abstract: (1592 Views)
Introduction: Folliculogenesis is a cycle that any disruption in this cycle leads to disease. Treatment include Surgery, drugs and low-power lasers have been used as complementary. This study investigated photo-bio-stimulation effect of lasers (power<250 mW)) on folliculogenesis cycle in rats’ ovarian tissue in two wavelength 630 and 810 nm autonomously.
Methods: Twenty-eight female Wistar rats in weights between 150-250g at the age of 9 weeks divided into four groups: control (CT), Drug(D), Red Laser (RL) and Near Infrared Laser (NIRL). For this, two diode lasers with an output 33±2 mw/cm2 for RL and 212±2 mw/cm2 for NIRL have been used. In the first 2 days of estrous cycle the laser groups were irradiated (5j/cm2 dose). The rats in D group received clomiphene (1µg/Kg). After the experiments, the rats were anesthetized and sacrificed and their ovarian tissues were removed.
Results: The number of different follicles and the levels of effective hormones were evaluated. The results showed a change in follicles and hormones compared with D and CT groups. This change was significant in the NIRL group compared with other groups, while it was not significant in the RL group. Theas results in D group was less than laser groups and was significant only compared with CT group.
Conclusions: Low-power laser therapy at 810 nm can increase the activity of ovarian tissue in the production of follicles independently. Therefore, this study was able to introduce 810 nm laser as a new independent treatment for ovarian hypoglycemia that can be used in future studies
Methods: Twenty-eight female Wistar rats in weights between 150-250g at the age of 9 weeks divided into four groups: control (CT), Drug(D), Red Laser (RL) and Near Infrared Laser (NIRL). For this, two diode lasers with an output 33±2 mw/cm2 for RL and 212±2 mw/cm2 for NIRL have been used. In the first 2 days of estrous cycle the laser groups were irradiated (5j/cm2 dose). The rats in D group received clomiphene (1µg/Kg). After the experiments, the rats were anesthetized and sacrificed and their ovarian tissues were removed.
Results: The number of different follicles and the levels of effective hormones were evaluated. The results showed a change in follicles and hormones compared with D and CT groups. This change was significant in the NIRL group compared with other groups, while it was not significant in the RL group. Theas results in D group was less than laser groups and was significant only compared with CT group.
Conclusions: Low-power laser therapy at 810 nm can increase the activity of ovarian tissue in the production of follicles independently. Therefore, this study was able to introduce 810 nm laser as a new independent treatment for ovarian hypoglycemia that can be used in future studies
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2021/02/27 | Accepted: 2021/08/24 | Published: 2021/12/1
Received: 2021/02/27 | Accepted: 2021/08/24 | Published: 2021/12/1
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