Volume 15, Issue 2 (Summer 2023)
2023, 15(2): 13-21 |
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Ethics code: NEYSHABUR.REC.1401.007
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Javadi Kia M, Barjaste Yazdi A, Khajei R, Hosein Abadi M R. Effect of High-Intensity Interval Training and Portulaca Oleracea Extract on C-Reactive Protein and Tumor Necrosis Factor-α in Rats with Nonalcoholic Fatty Liver Disease. North Khorasan University of Medical Sciences 2023; 15 (2) :13-21
URL: http://journal.nkums.ac.ir/article-1-2779-en.html
URL: http://journal.nkums.ac.ir/article-1-2779-en.html
1- Ph.D Student of Exercise Physiology, Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2- Assistant Professor of Exercise Physiology, Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
3- Assistant Professor of Corrective Movements, Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2- Assistant Professor of Exercise Physiology, Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
3- Assistant Professor of Corrective Movements, Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
Abstract: (738 Views)
Introduction: The present study aimed to investigate the effect of High-Intensity Interval Training (HIIT) and Portulaca Oleracea extract on serum levels of C-Reactive Protein (CRP) and Tumor Necrosis Factor-α (TNF-α) in rats with nonalcoholic fatty liver disease (NAFLD).
Method: A total of 25 male Wistar rats were randomly divided into five groups: healthy control, fatty liver control, Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleracea extract. To induce NAFLD, the rats were fed a high-fat diet for 12 weeks. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for eight weeks, five sessions per week with seven repetitions of 1 minute at 90% maximum speed accompanied by active rest intervals, including 2 minutes of running at 20% maximum speed.
Results: Serum levels of C-Reactive Protein and Tumor Necrosis Factor-α in Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleraceagroups extract groups were significantly lower than the fatty liver control group (P<0.05).
Conclusion: As evidenced by the results of this study, HIIT alone and combined with Portulaca Oleracea extract can exert positive effects on liver inflammation in patients with NAFLD and prevent disease progression
Method: A total of 25 male Wistar rats were randomly divided into five groups: healthy control, fatty liver control, Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleracea extract. To induce NAFLD, the rats were fed a high-fat diet for 12 weeks. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for eight weeks, five sessions per week with seven repetitions of 1 minute at 90% maximum speed accompanied by active rest intervals, including 2 minutes of running at 20% maximum speed.
Results: Serum levels of C-Reactive Protein and Tumor Necrosis Factor-α in Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleraceagroups extract groups were significantly lower than the fatty liver control group (P<0.05).
Conclusion: As evidenced by the results of this study, HIIT alone and combined with Portulaca Oleracea extract can exert positive effects on liver inflammation in patients with NAFLD and prevent disease progression
Keywords: C-Reactive Protein, High-Intensity Interval Training, Nonalcoholic Fatty Liver, Portulaca Oleracea extract, Tumor Necrosis Factor-α
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2022/11/23 | Accepted: 2023/04/16 | Published: 2023/08/26
Received: 2022/11/23 | Accepted: 2023/04/16 | Published: 2023/08/26
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