Volume 16, Issue 2 (Summer 2024)
2024, 16(2): 83-90 |
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Ethics code: IR.NKUMS.REC.1400.174
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Imani V, Pourabbas M R, Zarghami Moghaddam P, Baqeri M, Shakeri F. In vitro Study of the Synergistic Effect of Different Concentrations of Chlorhexidine Mouthwash and Ethanolic Extract of Pinus Gerardiana on Oral Pathogens (Streptococcus Mutans and Candida Albicans). North Khorasan University of Medical Sciences 2024; 16 (2) :83-90
URL: http://journal.nkums.ac.ir/article-1-2999-en.html
URL: http://journal.nkums.ac.ir/article-1-2999-en.html
Vahab Imani1 
, Mohammad Reza Pourabbas2 , Parastoo Zarghami Moghaddam3 , Mina Baqeri4 , Farzaneh Shakeri *5
, Mohammad Reza Pourabbas2 , Parastoo Zarghami Moghaddam3 , Mina Baqeri4 , Farzaneh Shakeri *5
1- Doctor of General Dentistry, Faculty of Dentistry, North Khorasan University of medical science, Bojnurd, Iran
2- Dental Student, Faculty of Dentistry, North Khorasan University of medical sciences, Bojnurd, Iran
3- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Faculty of Dentistry, North Khorasan University of medical sciences, Bojnurd, Iran
5- Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,f_1366_sh@yahoo.com
2- Dental Student, Faculty of Dentistry, North Khorasan University of medical sciences, Bojnurd, Iran
3- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Faculty of Dentistry, North Khorasan University of medical sciences, Bojnurd, Iran
5- Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,
Abstract: (816 Views)
Introduction: Tooth decay is the most common chronic disease in the world. Streptococcus mutans is the most important bacteria that cause tooth decay. The most common chemical method to prevent tooth decay is using mouthwash. Chlorhexidine is used as a standard mouthwash. The use of herbal compounds with antibacterial effect is preferable to chlorhexidine due to less side effects. The purpose of this study was to investigate the combination of different concentrations of chlorhexidine mouthwash and ethanol extract of Pinus gerardiana medicinal plant on oral pathogens (Streptococcus mutans and Candida albicans).
Method: A combination of different concentrations of chlorhexidine mouthwash and ethanol extract of Pinus gerardiana medicinal plant was prepared and its effect in different dilution against Streptococcus mutans and Candida albicans was investigated by disc diffusion, well diffusion, and prevention of biofilm formation methods.
Results: The results of disc diffusion, well diffusion, and biofilm method showed that the ethanolic extract of Pinus gerardiana medicinal plant alone had no significant antimicrobial effect on Streptococcus mutans and Candida albicans and it was not comparable to chlorhexidine.
Conclusion: According to the findings of this study, the antibacterial and antifungal effects of chlorhexidine gradually increased with the increase in concentration, and 0.2% chlorhexidine had the highest inhibitory effect on bacteria and fungi under the present study.
Method: A combination of different concentrations of chlorhexidine mouthwash and ethanol extract of Pinus gerardiana medicinal plant was prepared and its effect in different dilution against Streptococcus mutans and Candida albicans was investigated by disc diffusion, well diffusion, and prevention of biofilm formation methods.
Results: The results of disc diffusion, well diffusion, and biofilm method showed that the ethanolic extract of Pinus gerardiana medicinal plant alone had no significant antimicrobial effect on Streptococcus mutans and Candida albicans and it was not comparable to chlorhexidine.
Conclusion: According to the findings of this study, the antibacterial and antifungal effects of chlorhexidine gradually increased with the increase in concentration, and 0.2% chlorhexidine had the highest inhibitory effect on bacteria and fungi under the present study.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2023/07/20 | Accepted: 2024/02/27 | Published: 2024/06/29
Received: 2023/07/20 | Accepted: 2024/02/27 | Published: 2024/06/29
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