Volume 16, Issue 3 (Autumn 2024)
2024, 16(3): 13-27 |
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Ethics code: IR.MUMS.MEDICAL.REC.1401.709
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Maharati A, Moghbeli M. Role of microRNA-30e during tumor progression and metastasis. North Khorasan University of Medical Sciences 2024; 16 (3) :13-27
URL: http://journal.nkums.ac.ir/article-1-3057-en.html
URL: http://journal.nkums.ac.ir/article-1-3057-en.html
1- M.D. Student, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant Professor, Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,moghbelim@mums.ac.ir
2- Assistant Professor, Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (607 Views)
Despite the recent progress in diagnostic and therapeutic methods, there is still a high rate of cancer-related deaths in the world. Late diagnosis and drug resistance can be considered as the main reasons for the high mortality rate among cancer patients. Lack of appropriate non-invasive diagnostic methods in cancer patients is associated with late diagnosis. Therefore, investigation of the molecular mechanisms of tumorigenesis is required to suggest the non-invasive diagnostic tumor markers. MicroRNAs (miRNAs) are the key regulators of cell proliferation, apoptosis, differentiation, and migration. Hence, miRNA deregulation can be involved in tumor progression. This study aimed to investigate the role of miR-30e during tumor progression. It has been shown that miR-30e mainly has a tumor suppressor role via the regulation of PI3K/AKT signaling, ubiquitin-proteasome system, transcription factors, autophagy, and epithelial-mesenchymal transition. This review can be a valuable step toward the suggestion of miR-30e as a therapeutic target and non-invasive diagnostic marker in cancer patients.
Type of Study: Review Article |
Subject:
Basic Sciences
Received: 2024/05/1 | Accepted: 2024/06/26 | Published: 2024/09/24
Received: 2024/05/1 | Accepted: 2024/06/26 | Published: 2024/09/24
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