Volume 16, Issue 3 (Autumn 2024)
2024, 16(3): 109-118 |
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Ethics code: IR.SSRI.REC.1400.1168
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Movahed S, Bashiri J, Pourrazi H, Poozesh Jadidi R. The effect of aerobic exercise and food restriction on the expression of alpha-synuclein and sirtuin-1 proteins in the brain tissue of parkinson rats model. North Khorasan University of Medical Sciences 2024; 16 (3) :109-118
URL: http://journal.nkums.ac.ir/article-1-3068-en.html
URL: http://journal.nkums.ac.ir/article-1-3068-en.html
1- PhD Student of Sports Physiology, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- Associate Professor of Sports Physiology, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran ,bashiri.jabbar@iaut.ac.ir
3- Assistant Professor of Sports Physiology, Department of Physical Education and Sports Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
4- Assistant Professor, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- Associate Professor of Sports Physiology, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran ,
3- Assistant Professor of Sports Physiology, Department of Physical Education and Sports Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
4- Assistant Professor, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract: (743 Views)
Introduction: Alpha-synuclein and sirtuin-1 proteins are genetically and neuropathologically related to the Parkinson's disease. This study aimed to investigate the effect of 12 weeks of aerobic exercise and food restriction on the expression of alpha-synuclein and sirtuin-1 proteins in the brain tissue of Parkinsonian rats.
Method: In the current experimental study, 40 white male Wistar rats were randomly divided into five groups of 8 series, including healthy control, Parkinson's control, exercise parkinsonism, food restriction parkinsonism, and exercise+food restriction parkinsonism. The exercise program consisted of 3 months and five weekly sessions with an intensity of 75-80% oxygen consumption. According to the food restriction, the daily intake of each rat was determined to be 11 grams. The western blot method used to determine the expression levels of alpha-synuclein and sirtuin-1 proteins. Data were analyzed using a two-way analysis of variance and Tukey's test with SPSS25 software.
Results: There was a significant difference in alpha-synuclein and sirtuin-1 in healthy and Parkinson's rats. The expression of alpha-synuclein in the food restriction+aerobic exercise group significantly decreased compared to the Parkinson's control group (P=0.001). Also, a significant increase in sirtuin-1 was observed in the aerobic training+food restriction group compared to the Parkinson's control group (P=0.001).
Conclusion: Three months of aerobic activity have a positive effect on increasing sirtuin-1 and decreasing alpha-synuclein in the hippocampus of rat model of Parkinson, while the effect of exercise with food restriction is greater. Therefore, aerobic exercise and moderate food restriction are recommended as a method of treatment for patients with Parkinson's, with drug interventions.
Method: In the current experimental study, 40 white male Wistar rats were randomly divided into five groups of 8 series, including healthy control, Parkinson's control, exercise parkinsonism, food restriction parkinsonism, and exercise+food restriction parkinsonism. The exercise program consisted of 3 months and five weekly sessions with an intensity of 75-80% oxygen consumption. According to the food restriction, the daily intake of each rat was determined to be 11 grams. The western blot method used to determine the expression levels of alpha-synuclein and sirtuin-1 proteins. Data were analyzed using a two-way analysis of variance and Tukey's test with SPSS25 software.
Results: There was a significant difference in alpha-synuclein and sirtuin-1 in healthy and Parkinson's rats. The expression of alpha-synuclein in the food restriction+aerobic exercise group significantly decreased compared to the Parkinson's control group (P=0.001). Also, a significant increase in sirtuin-1 was observed in the aerobic training+food restriction group compared to the Parkinson's control group (P=0.001).
Conclusion: Three months of aerobic activity have a positive effect on increasing sirtuin-1 and decreasing alpha-synuclein in the hippocampus of rat model of Parkinson, while the effect of exercise with food restriction is greater. Therefore, aerobic exercise and moderate food restriction are recommended as a method of treatment for patients with Parkinson's, with drug interventions.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2024/01/20 | Accepted: 2024/04/16 | Published: 2024/09/24
Received: 2024/01/20 | Accepted: 2024/04/16 | Published: 2024/09/24
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