Volume 18, Issue 2 (Summer 2026)
2026, 18(2): 12-25 |
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Sadeghian-Nodoushan F, Ahmadirad N, Kuchakzade F, Babaloo H. Applications of Mesenchymal Stem Cells in Spinal Cord Injury Repair: A Review of Advances, Mechanisms, and Recent Clinical Studies. North Khorasan University of Medical Sciences 2026; 18 (2) :12-25
URL: http://journal.nkums.ac.ir/article-1-3381-en.html
URL: http://journal.nkums.ac.ir/article-1-3381-en.html
1- Assistant Professor, Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2- Assistant Professor, Cellular and Molecular Research Center, Iran University of Medical Sciences and Health Services, Tehran, Iran
3- Assistant Professor, Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran ,hbabaloo92@gmail.com
2- Assistant Professor, Cellular and Molecular Research Center, Iran University of Medical Sciences and Health Services, Tehran, Iran
3- Assistant Professor, Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran ,
Abstract: (34 Views)
Introduction: Spinal cord injury (SCI) is a traumatic condition that causes sensory and motor deficits, affecting more than one million people worldwide. Current pharmacological treatments can only reduce injury severity and prevent further damage to the central nervous system, but none have succeeded in promoting axonal regeneration. In recent years, cell therapy has emerged as a promising regenerative approach for treating SCI.
Methods: In this review, articles published between 2006 and 2025 were retrieved from ISI Web of Science, ScienceDirect, Scopus, PubMed, and Google Scholar databases. Keywords such as Spinal Cord Injury, Stem Cells, Central Nervous System, and Mesenchymal Stem Cells were used for the search. Articles were screened based on their titles and abstracts, and irrelevant studies were excluded.
Results: The findings indicated that mesenchymal stem cells (MSCs) can improve neurological function after SCI through the secretion of neurotrophic factors, modulation of immune responses, differentiation into neural cells, and induction of neuroprotective and remyelination effects. Clinical studies have also reported improvements in patients’ sensory and motor function, although variations in cell sources, dosing, delivery route, and timing have led to inconsistent outcomes.
Conclusions: Overall, evidence suggests that MSC transplantation represents a safe and effective strategy for treating spinal cord injuries. However, limitations such as small sample sizes, lack of control groups, and heterogeneity in transplantation protocols highlight the need for larger clinical trials and standardized therapeutic procedures
Methods: In this review, articles published between 2006 and 2025 were retrieved from ISI Web of Science, ScienceDirect, Scopus, PubMed, and Google Scholar databases. Keywords such as Spinal Cord Injury, Stem Cells, Central Nervous System, and Mesenchymal Stem Cells were used for the search. Articles were screened based on their titles and abstracts, and irrelevant studies were excluded.
Results: The findings indicated that mesenchymal stem cells (MSCs) can improve neurological function after SCI through the secretion of neurotrophic factors, modulation of immune responses, differentiation into neural cells, and induction of neuroprotective and remyelination effects. Clinical studies have also reported improvements in patients’ sensory and motor function, although variations in cell sources, dosing, delivery route, and timing have led to inconsistent outcomes.
Conclusions: Overall, evidence suggests that MSC transplantation represents a safe and effective strategy for treating spinal cord injuries. However, limitations such as small sample sizes, lack of control groups, and heterogeneity in transplantation protocols highlight the need for larger clinical trials and standardized therapeutic procedures
Type of Study: Review Article |
Subject:
Basic Sciences
Received: 2025/10/28 | Accepted: 2026/02/7 | Published: 2026/07/1
Received: 2025/10/28 | Accepted: 2026/02/7 | Published: 2026/07/1
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