Journal of North Khorasan

Abstract Background: Cardiovascular disease is one of the maincauses of mortality in worldwide. In most cases, the underlying cause is atherosclerosis. Periodontal disease as an infective disease can cause atherosclerosis. The aim of this study is the evaluation of periodontal disease effect on the development of cardiovascular disease and the review of its mechanism. Material & Methods: The article is resulted from the review of reliable scientific articles regarding to the mechanism of periodontal disease effect on cardiovascular system and the emergence of associated diseases and ultimately, the collection of data about this issue. Result: Multiple studies have been reported about the relationship between periodontal and cardiovascular diseases. In these articles, the role of periodontal disease in the development of atherosclerosis and its mechanism were evaluated, and several factorswere referred as effective causes, such as direct invasion of periodontal pathogen to atherosclerotic plaques, pro-inflammatory cytokines effect, pro-coagulation effects of the periodontal pathogen, and increased activity of platelets and white blood cells. Conclusion: As regards the infection is able to alter lipid metabolism by immune cells, the role of periodontal disease as an infective diseasecan be referred in the development of atherosclerosis and othercardiovascular diseases. Thus, it’s suggested that people must be informed about the importance of oral hygiene, and they should acquire some necessary information about negative effect of periodontal disease on cardiovascular system and the importance of familiarity with primary signs of the disease for early diagnosis and treatment.