Journal of North Khorasan

Background & Objectives:The purpose of this study is to evaluate the immunohistochemical expression of CD105 and Bcl2 in radicular cyst, dentigerous cyst, OKC and ameloblastoma.

Material and methods: In this analytical retrospective study, 15 samples of radicular cyst, 15 dentigerous cyst, 15 OKC and 5 samples of ameloblastoma were selected. The samples were deparafinized and antigens were retrieved. Immunohistochemistry technique was applied for evaluation of CD105 and bcl2. Findings were analyzed by SPSS17 software. Comparative analysis of data was performed by using the Mann-Whitney T-test for two independent samples. A p value of less than 0.05 was considered to be statistically significant.

Results: The mean value of bcl2 expression in radicular, dentigerous, OKC and ameloblastma were  78,71.13, 48 and 45 respectively. There is no significant difference between OKC and ameloblastoma(p >0.05). The percentage of CD105 positive vessels was higher in radicular cyst and decreased in dentigerous cyst, OKC and ameloblastoma.

Conclusion: The higher expression of bcl2 in OKC and ameloblastoma can explain the more aggressive clinical behavior of these lesions, although, angiogenesis has no impression on it.

Keywords: radicular cyst, dentigerus cyst, OKC, ameloblastoma, CD105 and bcl2,Immunohistochemistry.