Abstract Background & Objectives: The common pattern of drug use in Iran was opioid drug in the past few years. But this pattern has been changed to methamphetamine these days. Regarding to this changing this study aims to compare the personality traits and irrational beliefs between opioid dependants and methamphetamine abusers. Material & Methods: 119 addicted women including 59 addicted to opium and 60 addicted to methamphetamine referred to welfare, MMT and temporary campus centers of Shirvan were selected and asked to complete the NEO personality scale and Jones`s Irrational beliefs questionnaire. The data were analyzed with SPSS- 15 and presented with t -test. Result: The subscales of perfectionism and avoidance of issues and reaction to failures, industrial materials consumer group had higher scores. About the characteristics of people addicted to methamphetamine showed higher scores on conscientiousness and agreeableness (α = 0.95%). Conclusion: results showed that there is no significant difference between two groups in terms total score of irrational belief, notwithstanding in some subscales showed significant level of difference. Methamphetamine abusers have a high score in conscientiousness and agreeableness(α=0.95% )
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