Volume 1, Issue 1 (Autumn2008 2008)
2008, 1(1): 33-40 |
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Derakhshande H, Aman Allahi F. Evaluation of green tea consumption on level of blood cholesterol on rat. . North Khorasan University of Medical Sciences 2008; 1 (1) :33-40
URL: http://journal.nkums.ac.ir/article-1-428-en.html
URL: http://journal.nkums.ac.ir/article-1-428-en.html
1- , pharmacy-mashad@yahoo.com
Abstract: (4706 Views)
Introduction: Green tea with scientific name Camellia Sciensis is the most popular medicinal herbs in Asia. Epidemiological studies have shown that the derivatives of catechin compounds from green tea have reducing of cholesterol levels in plasma effects. The purpose of this study is evaluation of the effect of green tea water extract on cholesterol levels in rats.
Methods: 32 rats with 200±10 g and 2-4 month properties divided in 4 groups contain A: negative control; B: positive control (nicotinic acid); C: treatment with water extract and D: prevention with water extract. We used Cholesterol-rich foods 2% for preparation of hyperlipidemia conditions. At first D group has been feed with extract and enriched food. B and C groups were feeded by nicotinic acid 25 mg/kg/day and water extract after a significant increase in fat levels at the end of sixth week. Water extract of green tea was produced by extraction with water and ethyl acetate and after the solvent removal, in 100 mg/kg/day with gavage method was fed to animals. The level of cholesterol (Ch), triglyceride (TG), LDL, HDL and weight of animals were measured each week. The results were shown in Mean±SEM status. The effect of using the green tea extract on blood cholesterol level was analyzed by ANOVA and Unpaired t-test. P<0.05 was considered as a meaningful level of data.
Results: In C group, the levels of Ch (P<0.001-33.3%), TG (P<0.001-40.7%), LDL (P<0.001-30.2%) and HDL (P<0.001-40%) were reduced. Data alignment in D group and changes average 10% (P<0.001) in levels of study, indicate the fixing of cholesterol in blood. In positive group control the using of nicotinic acid, reduced the intended levels of plasma (P<0.001). Checking the weight of rats showed reducing of weight in groups that were exposed to extract (P<0.01).
Conclusion: Comparison of positive control with treatment and prevention groups is indicative of antihyperlipidemia effect of water extract of green tea. Based on this study, consuming of green tea on a daily basis with a proper diet has an effective role in reducing the risk of high blood lipid.
Methods: 32 rats with 200±10 g and 2-4 month properties divided in 4 groups contain A: negative control; B: positive control (nicotinic acid); C: treatment with water extract and D: prevention with water extract. We used Cholesterol-rich foods 2% for preparation of hyperlipidemia conditions. At first D group has been feed with extract and enriched food. B and C groups were feeded by nicotinic acid 25 mg/kg/day and water extract after a significant increase in fat levels at the end of sixth week. Water extract of green tea was produced by extraction with water and ethyl acetate and after the solvent removal, in 100 mg/kg/day with gavage method was fed to animals. The level of cholesterol (Ch), triglyceride (TG), LDL, HDL and weight of animals were measured each week. The results were shown in Mean±SEM status. The effect of using the green tea extract on blood cholesterol level was analyzed by ANOVA and Unpaired t-test. P<0.05 was considered as a meaningful level of data.
Results: In C group, the levels of Ch (P<0.001-33.3%), TG (P<0.001-40.7%), LDL (P<0.001-30.2%) and HDL (P<0.001-40%) were reduced. Data alignment in D group and changes average 10% (P<0.001) in levels of study, indicate the fixing of cholesterol in blood. In positive group control the using of nicotinic acid, reduced the intended levels of plasma (P<0.001). Checking the weight of rats showed reducing of weight in groups that were exposed to extract (P<0.01).
Conclusion: Comparison of positive control with treatment and prevention groups is indicative of antihyperlipidemia effect of water extract of green tea. Based on this study, consuming of green tea on a daily basis with a proper diet has an effective role in reducing the risk of high blood lipid.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2015/03/28 | Accepted: 2015/03/28 | Published: 2015/03/28
Received: 2015/03/28 | Accepted: 2015/03/28 | Published: 2015/03/28
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