Volume 9, Issue 3 (12-2017)
2017, 9(3): 336-344 |
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Gholami Bahnemiri M, Kavosi Hajiabadi M, Tohidi F, Taravati A, Esmaeili A H. Investigation of Antioxidant and Antihemolytic Activities of Leaf Hydroalcoholic Extracts of Haussknechtia elymatica. North Khorasan University of Medical Sciences 2017; 9 (3) :336-344
URL: http://journal.nkums.ac.ir/article-1-1283-en.html
URL: http://journal.nkums.ac.ir/article-1-1283-en.html
Mehdi Gholami Bahnemiri1 
, Masomeh Kavosi Hajiabadi2 , Fatemeh Tohidi3 , Ali Taravati4 , Amir Hossein Esmaeili * 2
, Masomeh Kavosi Hajiabadi2 , Fatemeh Tohidi3 , Ali Taravati4 , Amir Hossein Esmaeili * 2
1- PhD Candidate, Deparment of Biochemistry-Biophysics, Babol University of Medical Sciences, Babol, Iran
2- MSc, Department of Laboratory Science, Babol-Branch, Islamic Azad University, Babol, Iran
3- Assistant Professor, Department of Microbiology. Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
4- Assistant Professor, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
2- MSc, Department of Laboratory Science, Babol-Branch, Islamic Azad University, Babol, Iran
3- Assistant Professor, Department of Microbiology. Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
4- Assistant Professor, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
Abstract: (4763 Views)
Introduction: Detrimental effect of free radicals in the body could be reduced using rich source of antioxidants. In this research, for the first time, antioxidant and antihemolytic activities of Haussknechtia elymatica leaf extract, as a strain of the Apiaceae family, were studied.
Methods: Samples were collected from mountain areas of Yasooj city. Leaf ethanolic extract was prepared by the soaking method. Phytochemical compounds was evaluated by GC/MS. Total phenolic and flavonoid contents were measured by folin-ciocalteu and colorimetric methods, respectively. The methods of Ferric-Reducing Antioxidant Power (FRAP), scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, and nitric oxide were used to evaluate antioxidant activity of the extract, and in vitro antihemolytic activity against H2O2 was also measured.
Results: The analysis of ethanolic extract by GC/MS showed that asarone at 49.40% is the most important phenolic component of this plant. In addition, the phenolic content of extract (39.6 ± 0.5 mg/g) was higher than the flavonoid content (17.3 ± 1.1 mg/g). The IC50 value of the extract in scavenging of DPPH and Nitric oxide radicals was 62.19 μg/mL and 223.90 μg/mL, respectively. The total antioxidant activity and consequently reducing power of extract increased proportional to its concentration. However, the extract showed weak antihemolytic activity.
Conclusions: The results showed that ethanolic leaf extract of Haussknechtia elymatica had strong antioxidant activity. Thus, it seems necessary to study different parts of this plant.
Methods: Samples were collected from mountain areas of Yasooj city. Leaf ethanolic extract was prepared by the soaking method. Phytochemical compounds was evaluated by GC/MS. Total phenolic and flavonoid contents were measured by folin-ciocalteu and colorimetric methods, respectively. The methods of Ferric-Reducing Antioxidant Power (FRAP), scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, and nitric oxide were used to evaluate antioxidant activity of the extract, and in vitro antihemolytic activity against H2O2 was also measured.
Results: The analysis of ethanolic extract by GC/MS showed that asarone at 49.40% is the most important phenolic component of this plant. In addition, the phenolic content of extract (39.6 ± 0.5 mg/g) was higher than the flavonoid content (17.3 ± 1.1 mg/g). The IC50 value of the extract in scavenging of DPPH and Nitric oxide radicals was 62.19 μg/mL and 223.90 μg/mL, respectively. The total antioxidant activity and consequently reducing power of extract increased proportional to its concentration. However, the extract showed weak antihemolytic activity.
Conclusions: The results showed that ethanolic leaf extract of Haussknechtia elymatica had strong antioxidant activity. Thus, it seems necessary to study different parts of this plant.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2017/12/31 | Accepted: 2017/12/31 | Published: 2017/12/31
Received: 2017/12/31 | Accepted: 2017/12/31 | Published: 2017/12/31
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53. Gill SS, Tuteja N. Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Plant Physiol Biochem. 2010;48(12):909-30. DOI: 10.1016/j.plaphy.2010.08.016PMID: 20870416
54. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004;266(1-2):37-56. PMID: 15646026 [DOI:10.1023/B:MCBI.0000049134.69131.89]
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57. Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res. 2008;68(3):946-55. DOI: 10.1158/0008-5472.CAN-07-3140PMID: 18245498
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61. Pokorny J, Yanishlieva N, Gordon M. Antioxidants in food: practical applications: CRC press; 2001.
62. Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci. 2002;7(9):405-10. PMID: 12234732 [DOI:10.1016/S1360-1385(02)02312-9]
63. White E, Shannon JS, Patterson RE. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev. 1997;6(10):769-74. PMID: 9332757
64. Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem. 2005;16(10):577-86. DOI: 10.1016/j.jnutbio.2005.05.013PMID: 16111877
65. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem. 2005;12(10):1161-208. PMID: 15892631 [DOI:10.2174/0929867053764635]
66. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1-40. DOI: 10.1016/j.cbi.2005.12.009PMID: 16430879
67. Forceville X, Laviolle B, Annane D, Vitoux D, Bleichner G, Korach JM, etal. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care. 2007;11(4):R73. DOI: 10.1186/cc5960PMID: 17617901
68. Ray PD, HuangBW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981-90. DOI: 10.1016/j.cellsig.2012.01.008PMID: 22286106
69. Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr. 2005;81(1 Suppl):268S-76S. PMID: 15640490
70. Huang D-J, Chun-Der L, Hsien-Jung C, Yaw-Huei L. Antioxidant and antiproliferative activities of sweet potato (Ipomoea batatas [L.] LamTainong 57') constituents. Botan Bull Acad Sinica. 2004;45.
71. Ghasemi K, Ghasemi Y, Ebrahimzadeh MA. Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci. 2009;22(3):277-81. PMID: 19553174
72. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Fazelian M, Eslami B. In vitro antioxidant and free radical scavenging activity of Diospyros lotus and Pyrus boissieriana growing in Iran. Pharmacogn Mag. 2009;5(18):122.
73. Kooti W, Ali-Akbari S, Asadi-Samani M, Ghadery H, Ashtary-Larky D. A review on medicinal plant of Apium graveolens. Adv Herb Med. 2015;1(1):48-59.
74. Saini N, Singh GK, Nagori BP. Spasmolytic Potential of Some Medicinal Plants Belonging to Family Umbelliferae: A Review. Int J Res Ayurveda Pharm. 2014;5(1):74-83. DOI: 10.7897/2277-4343.05116 [DOI:10.7897/2277-4343.05116]
75. Amirghofran Z, Azadmehr A, Javidnia K. Haussknechtia elymatica: a plant with immunomodulatory effects. Iran J Immunol. 2007;4(1):26-32.
76. Singleton VL, Orthofer R, Lamuela-Raventós RM. [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods Enzymol. 1999;299:152-78. DOI: 10.1016/s0076-6879(99)99017-1 [DOI:10.1016/S0076-6879(99)99017-1]
77. Chang C-C, Yang M-H, Wen H-M, Chern J-C. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10(3).
78. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996;239(1):70-6. DOI: 10.1006/abio.1996.0292PMID: 8660627
79. de Pinedo AT, Penalver P, Pérez-Victoria I, Rondón D, Morales J. Synthesis of new phenolic fatty acid esters and their evaluation as lipophilic antioxidants in an oil matrix. Food Chem. 2007;105(2):657-65. [DOI:10.1016/j.foodchem.2007.04.029]
80. Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agricult Food Chem. 1992;40(6):945-8. DOI: 10.1021/jf00018a005 [DOI:10.1021/jf00018a005]
81. Sreejayan, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 1997;49(1):105-7. PMID: 9120760 [DOI:10.1111/j.2042-7158.1997.tb06761.x]
82. Yen G-C, Chen H-Y. Antioxidant Activity of Various Tea Extracts in Relation to Their Antimutagenicity. J Agricult Food Chem. 1995;43(1):27-32. DOI: 10.1021/jf00049a007 [DOI:10.1021/jf00049a007]
83. Naim M, Gestetner B, Bondi A, Birk Y. Antioxidative and antihemolytic activities of soybean isoflavones. J Agricult Food Chem. 1976;24(6):1174-7. DOI: 10.1021/jf60208a029 [DOI:10.1021/jf60208a029]
84. Ahangarpour A, Zamaneh HT, Jabari A, Nia HM, Heidari H. Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats. Iran J Basic Med Sci. 2014;17(10):808-14. PMID: 25729552
85. Wollenweber E, Dörr M, Rustiyan A. Dorema aucheri, the first umbelliferous plant foundto produce exudate flavonoids. Phytochem. 1995;38(6):1417. DOI: 10.1016/0031-9422(94)00840-p [DOI:10.1016/0031-9422(94)00840-P]
86. Sadeghi H, Ghiasi I, Mazroughi N, Sabzali S. The hepatoprotective effects of Dorema auchri on carbon tetrachloride induced liver damage in rats. J Shahrekord Univ Med Sci. 2007;9(1):38-42.
87. Azarneoshan F, Khatam Saz S, Sadeghi H. The effects of hydro alcoholic extract of Dorema Aucheri on blood concentration of gonadotropin and androgen hormones in adult male rats. Armaghan J. 2009;14(3):63-70.
88. Rusdiana T, Sriwidodo S, Solahudin J, Halimah E, Irwan AW, Amin S, et al. In Vitro Test of Anticalculi Effect from Celery herb (Apium graveolens L.). Indonesian J Pharmac Sci Technol. 2015;2(2):63-7. DOI: 10.15416/ijpst.v2i2.7812 [DOI:10.15416/ijpst.v2i2.7812]
89. Coruh N, Sagdicoglu-Celep A, Özgökce F. Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food Chem. 2007;100:1237-42. [DOI:10.1016/j.foodchem.2005.12.006]
90. Massumi MA, Fazeli MR, Alavi SHR, Ajani Y. Chemical constituents and antibacterial activity of essential oil of Prangos ferulacea (L.) Lindl. fruits. Iranian J Pharmac Sci. 2007;3(3):171-6.
91. Panahi Y, Dadjou Y, Pishgoo B, Akbari A, Sahebkar A. AntioxidantActivity of Heracleum persicum Fruit Extract: Evidence from a Randomized Controlled Trial. J Diet Suppl. 2016;13(5):530-7. DOI: 10.3109/19390211.2015.1120842PMID: 26820395
92. Mohammadi M, Ghavidel M, Habibi Z, As'habiMA. Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron. Nat Prod Res. 2012;26(13):1229-33. DOI: 10.1080/14786419.2011.560848PMID: 22053735
93. Bamoniri A, Mazoochi A. Determination of bioactive and fragrant molecules from leaves and fruits of Ferula assa-foetida L. growing in central Iran by nanoscal injection. Digest J Nanomater Biostruct. 2009;4(2):323-8.
94. Mojab F, NickavarB. Composition of the Essential Oil of the Root of Heracleum persicum from Iran. Iranian J Pharmac Res. 2010:245-7.
95. Read MA. Flavonoids: naturally occurring anti-inflammatory agents. Am J Pathol. 1995;147(2):235-7. PMID: 7639322
96. Middleton E, Jr., Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol. 1992;43(6):1167-79. PMID: 1562270 [DOI:10.1016/0006-2952(92)90489-6]
97. Ebrahimzadeh M, Nabavi S, Eslami B, Nabavi S. Antioxidant and antihemolytic potentials of Physosperum cornubiense (L.) DC. Pharmacol. 2009;3:394-403.
98. Dunnick JK, Hailey JR. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol. 1992;19(3):423-31. PMID: 1459373 [DOI:10.1016/0272-0590(92)90181-G]
99. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Eslami B, Dehpour AA. Antioxidant and antihaemolytic activities of Ferula foetida regel (Umbelliferae). Eur Rev Med Pharmacol Sci. 2011;15(2):157-64. PMID: 21434482
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