Volume 17, Issue 3 (Autumn 2025)
2025, 17(3): 54-61 |
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Ethics code: IR.IAU.ILAM.REC.1403.072
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Bakhtiari Dehbalaei S, Pasandideh Fetrat H, Taheri Kalani A, Omidi M. Effect of Aerobic Training on TLR4 and NLRP3 Gene Expression in the Cerebellum of Rat Models of Parkinson’s Disease. North Khorasan University of Medical Sciences 2025; 17 (3) :54-61
URL: http://journal.nkums.ac.ir/article-1-3265-en.html
URL: http://journal.nkums.ac.ir/article-1-3265-en.html
Somayeh Bakhtiari Dehbalaei1 
, Hojat Pasandideh Fetrat1 , Abdolhossein Taheri Kalani *2 , Mahnaz Omidi3
, Hojat Pasandideh Fetrat1 , Abdolhossein Taheri Kalani *2 , Mahnaz Omidi3
1- Master of Exercise Physiology, Department of Exercise Physiology, Il.C, Islamic Azad University, Ilam, Iran
2- Assistant Professor, Department of Exercise Physiology, Il.C, Islamic Azad University, Ilam, Iran ,htaheriedu@gmail.com
3- Assistant Professor, Department of Exercise Physiology, Il.C, Islamic Azad University, Ilam, Iran
2- Assistant Professor, Department of Exercise Physiology, Il.C, Islamic Azad University, Ilam, Iran ,
3- Assistant Professor, Department of Exercise Physiology, Il.C, Islamic Azad University, Ilam, Iran
Abstract: (243 Views)
Introduction: Extensive human and animal studies have demonstrated the role of inflammation in the initiation and development of Parkinson's disease (PD). The present study aimed to compare the effect of two types of aerobic training on the gene expression of the TLR4 and NLRP3 inflammatory pathways in the cerebellum of rat models of PD.
Method: In this experimental study, 28 male Wistar rats were randomly divided into four groups: control, Parkinson, Parkinson+continuous training (CT), and Parkinson+interval training (IT). The PD was induced by injecting 2 mg/kg rotenone in animals, CT consisted of 15-40 min, and IT included 2-6 sets running on the treadmill at a speed of 10-20 m/min for six weeks. The rats were sacrificed 48 h after the last training session, and gene expression of TLR4 and NLRP3 in the cerebellum was measured using the real-time PCR technique.
Results: There was a significant decrease in the TLR4 and NLRP3 expression in the control compared to other groups (all; P=0.0001). Moreover, the levels of TLR4 and NLRP3 expression in the Parkinson group showed a significant decline compared to the Parkinson+CT and Parkinson+IT groups (both, P=0.0001). However, there was no significant difference in the levels of TLR4 and NLRP3 expression between the Parkinson+CT and Parkinson+IT groups (P=0.309 and P=0.103, respectively).
Conclusion: Both CT and IT were similarly effective in the reduction of TLR4 and NLRP3 in the cerebellar tissue of rat models of PD. Therefore, aerobic training can help to alleviate neuronal damage in PD by exerting anti-inflammatory effects.
Method: In this experimental study, 28 male Wistar rats were randomly divided into four groups: control, Parkinson, Parkinson+continuous training (CT), and Parkinson+interval training (IT). The PD was induced by injecting 2 mg/kg rotenone in animals, CT consisted of 15-40 min, and IT included 2-6 sets running on the treadmill at a speed of 10-20 m/min for six weeks. The rats were sacrificed 48 h after the last training session, and gene expression of TLR4 and NLRP3 in the cerebellum was measured using the real-time PCR technique.
Results: There was a significant decrease in the TLR4 and NLRP3 expression in the control compared to other groups (all; P=0.0001). Moreover, the levels of TLR4 and NLRP3 expression in the Parkinson group showed a significant decline compared to the Parkinson+CT and Parkinson+IT groups (both, P=0.0001). However, there was no significant difference in the levels of TLR4 and NLRP3 expression between the Parkinson+CT and Parkinson+IT groups (P=0.309 and P=0.103, respectively).
Conclusion: Both CT and IT were similarly effective in the reduction of TLR4 and NLRP3 in the cerebellar tissue of rat models of PD. Therefore, aerobic training can help to alleviate neuronal damage in PD by exerting anti-inflammatory effects.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/01/5 | Accepted: 2025/03/5 | Published: 2025/09/29
Received: 2025/01/5 | Accepted: 2025/03/5 | Published: 2025/09/29
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