Volume 17, Issue 4 (Winter 2026)
2026, 17(4): 10-20 |
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Zafarmand O, Molaei K, Salesi M. The Effect of Aerobic Exercise on Interleukin 6 and Interleukin 10 in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis. North Khorasan University of Medical Sciences 2026; 17 (4) :10-20
URL: http://journal.nkums.ac.ir/article-1-3313-en.html
URL: http://journal.nkums.ac.ir/article-1-3313-en.html
1- 1. MSc in Exercise Physiology, Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran
2- 2. MSc in Exercise Physiology, Department of Sports Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran ,kh.molaei2027@gmail.com
3- 3. Associate Professor, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran
2- 2. MSc in Exercise Physiology, Department of Sports Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran ,
3- 3. Associate Professor, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran
Abstract: (27 Views)
Introduction: Multiple sclerosis is a chronic autoimmune and inflammatory disease, for which exercise, especially aerobic activity, has been considered a disease-modifying treatment. Therefore, the present study aims to conduct a systematic review and meta-analysis of studies that investigated the effect of aerobic exercise on interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with multiple sclerosis.
Methods: A search was conducted across major databases, including PubMed, Web of Science, Scopus, SID, and Magiran, up to February 22, 2025, for studies comparing aerobic exercise with a control on the cytokines IL-6 and IL-10. The effect size was calculated using the standardized mean difference and a 95% confidence interval, using CMA2 software.
Findings: This meta-analysis included seven studies involving 295 people with multiple sclerosis. The results indicated that aerobic exercise in patients with multiple sclerosis leads to a non-significant decrease in IL-6 [WMD= -0.456 Pg/ml (0.266 to -1.178) P=0.216] and a non-significant increase in IL-10 [WMD= 0.447 Pg/ml (1.246 to -0.352) P=0.272] compared to the control group.
Conclusions: Aerobic exercises can enhance physical capacity, regulate and balance inflammatory and anti-inflammatory cytokines, and modify indicators that lead to a decrease in IL-6 and an increase in IL-10 in patients with multiple sclerosis. Specialists can incorporate these exercises as a complementary treatment alongside medications for these patients.
Methods: A search was conducted across major databases, including PubMed, Web of Science, Scopus, SID, and Magiran, up to February 22, 2025, for studies comparing aerobic exercise with a control on the cytokines IL-6 and IL-10. The effect size was calculated using the standardized mean difference and a 95% confidence interval, using CMA2 software.
Findings: This meta-analysis included seven studies involving 295 people with multiple sclerosis. The results indicated that aerobic exercise in patients with multiple sclerosis leads to a non-significant decrease in IL-6 [WMD= -0.456 Pg/ml (0.266 to -1.178) P=0.216] and a non-significant increase in IL-10 [WMD= 0.447 Pg/ml (1.246 to -0.352) P=0.272] compared to the control group.
Conclusions: Aerobic exercises can enhance physical capacity, regulate and balance inflammatory and anti-inflammatory cytokines, and modify indicators that lead to a decrease in IL-6 and an increase in IL-10 in patients with multiple sclerosis. Specialists can incorporate these exercises as a complementary treatment alongside medications for these patients.
Type of Study: Review Article |
Subject:
Basic Sciences
Received: 2025/02/25 | Accepted: 2025/05/13 | Published: 2026/01/1
Received: 2025/02/25 | Accepted: 2025/05/13 | Published: 2026/01/1
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