Volume 17, Issue 4 (Winter 2026)
2026, 17(4): 29-38 |
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Ethics code: IR.IAU.SRB.REC.1403.001
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Bahrami H, Gholami M, Abedi B. The Effect of Combined Training and L-arginine Supplementation on Insulin Resistance, Body Composition, and IL-6 Levels in Obese Men. North Khorasan University of Medical Sciences 2026; 17 (4) :29-38
URL: http://journal.nkums.ac.ir/article-1-3315-en.html
URL: http://journal.nkums.ac.ir/article-1-3315-en.html
1- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran ,m.gholami@srbiau.ac.ir
3- Department of Exercise Physiology, NT.C., Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran ,
3- Department of Exercise Physiology, NT.C., Islamic Azad University, Tehran, Iran
Abstract: (20 Views)
Introduction: Despite the anti-inflammatory effects of exercise training and L-arginine ingestion, the combined impact of these two interventions on various inflammatory mediators is still unknown. This study aimed to determine the effects of combined training and L-arginine ingestion on insulin resistance, body composition, and interleukin-6 (IL-6) levels in obese men.
Methods: The 48 obese men (average body mass index: 31.97±1.34 kg/m²) were randomly assigned to four groups (12 participants in each group), including a training group, an L-arginine group, a placebo group, and a training+L-arginine group. The exercise training was conducted in a combined type, consisting of resistance and endurance exercises, and was performed in three sessions per week for eight weeks. The L-arginine ingestion was six grams per day, which was consumed in two grams in three meals. The levels of glucose, insulin, and IL-6 were measured using specific kits, and the results were analyzed using SPSS software (version 24).
Results: The current study′s findings indicated a significant decrease in IL-6 levels in the training group compared to the placebo (p = 0.004) and L-arginine (p = 0.003) groups, as well as in the training+L-arginine group compared to the placebo (p = 0.002) and L-arginine (p = 0.002) groups. Insulin resistance also decreased significantly in the training and training+L-arginine groups compared to the placebo and L-arginine groups (p<0.001).
Conclusions: The current study's findings confirmed the anti-inflammatory effects of combined training, both with and without L-arginine supplementation. However, eight weeks of L-arginine supplementation did not significantly increase the anti-inflammatory effects of combined training in obese men.
Methods: The 48 obese men (average body mass index: 31.97±1.34 kg/m²) were randomly assigned to four groups (12 participants in each group), including a training group, an L-arginine group, a placebo group, and a training+L-arginine group. The exercise training was conducted in a combined type, consisting of resistance and endurance exercises, and was performed in three sessions per week for eight weeks. The L-arginine ingestion was six grams per day, which was consumed in two grams in three meals. The levels of glucose, insulin, and IL-6 were measured using specific kits, and the results were analyzed using SPSS software (version 24).
Results: The current study′s findings indicated a significant decrease in IL-6 levels in the training group compared to the placebo (p = 0.004) and L-arginine (p = 0.003) groups, as well as in the training+L-arginine group compared to the placebo (p = 0.002) and L-arginine (p = 0.002) groups. Insulin resistance also decreased significantly in the training and training+L-arginine groups compared to the placebo and L-arginine groups (p<0.001).
Conclusions: The current study's findings confirmed the anti-inflammatory effects of combined training, both with and without L-arginine supplementation. However, eight weeks of L-arginine supplementation did not significantly increase the anti-inflammatory effects of combined training in obese men.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/01/9 | Accepted: 2025/05/17 | Published: 2026/01/1
Received: 2025/01/9 | Accepted: 2025/05/17 | Published: 2026/01/1
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