Volume 15, Issue 3 (Autumn 2023)
2023, 15(3): 37-42 |
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Nooryazdan A, Zinivand M, Ghorbanzadeh V, Beiranvand H, Khalili Alborz A, Nazari A. Effect of Hydroalcoholic Extract of Ginger on Cardiac Parameters in Male Rats with Renovascular Hypertension. North Khorasan University of Medical Sciences 2023; 15 (3) :37-42
URL: http://journal.nkums.ac.ir/article-1-2824-en.html
URL: http://journal.nkums.ac.ir/article-1-2824-en.html
Aram Nooryazdan1 
, Mahtab Zinivand1 , Vajihe Ghorbanzadeh2 , Hossein Beiranvand1 , Azadeh Khalili Alborz3 , Afshin Nazari *4
, Mahtab Zinivand1 , Vajihe Ghorbanzadeh2 , Hossein Beiranvand1 , Azadeh Khalili Alborz3 , Afshin Nazari *4
1- Master of Science, Department of Medical Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran
2- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran
3- Assistant Professor, Department of Physiology, Pharmacology, and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran ,nazary257@yahoo.com
2- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran
3- Assistant Professor, Department of Physiology, Pharmacology, and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran ,
Abstract: (1217 Views)
Introduction: High blood pressure is one of the most important concerns of the healthcare system, especially in low- and middle-income countries. In the present study, we aimed to investigate the protective effect of the hydromethanolic extract of ginger on cardiac parameters in male rats with renovascular hypertension.
Method: A total of 54 rats were randomly divided into 6 groups as follows: control, hypertensive group, hypertensive group (hydromethanolic extract of ginger with a dose of 100 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 200 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 300 mg/kg), and surgical group receiving hydromethanolic extract of ginger with a dose of 200 mg/kg. Rats were gavaged for 42 days, once every day, using hydromethanol extract of ginger. Afterward, the heart rate was measured every 7 days. Ejection fraction (EF) and cardiac index were evaluated by SPSS-16 at a significance level of 0.05.
Results: The results of the study showed that the hydroethanolic extract of ginger caused a significant decrease in heart rate in the group without induced blood pressure receiving ginger extract (dose of 200 mg/kg) and in the induced blood pressure group gavaged ginger at a dose of 200 mg/kg. It was also found that there was a significant difference between the average EF in the studied groups; however, the cardiac index had no significant difference in the studied groups.
Conclusion: Hydroethanolic extract of ginger can reduce heart rate in hypertensive models and have a significant effect on cardiac output. Since ginger has no effect on cardiac index, studies with a longer duration of treatment are needed in this case, nevertheless, it can have a significant effect on ejection fraction
Method: A total of 54 rats were randomly divided into 6 groups as follows: control, hypertensive group, hypertensive group (hydromethanolic extract of ginger with a dose of 100 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 200 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 300 mg/kg), and surgical group receiving hydromethanolic extract of ginger with a dose of 200 mg/kg. Rats were gavaged for 42 days, once every day, using hydromethanol extract of ginger. Afterward, the heart rate was measured every 7 days. Ejection fraction (EF) and cardiac index were evaluated by SPSS-16 at a significance level of 0.05.
Results: The results of the study showed that the hydroethanolic extract of ginger caused a significant decrease in heart rate in the group without induced blood pressure receiving ginger extract (dose of 200 mg/kg) and in the induced blood pressure group gavaged ginger at a dose of 200 mg/kg. It was also found that there was a significant difference between the average EF in the studied groups; however, the cardiac index had no significant difference in the studied groups.
Conclusion: Hydroethanolic extract of ginger can reduce heart rate in hypertensive models and have a significant effect on cardiac output. Since ginger has no effect on cardiac index, studies with a longer duration of treatment are needed in this case, nevertheless, it can have a significant effect on ejection fraction
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2023/01/15 | Accepted: 2023/08/6 | Published: 2023/10/2
Received: 2023/01/15 | Accepted: 2023/08/6 | Published: 2023/10/2
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