Volume 18, Issue 2 (Summer 2026)
2026, 18(2): 26-34 |
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Ethics code: IR.SSU.MEDICINE.REC.1395.13
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Majdizadeh M, Mofakhamipor-Mehrabadi A, Sheikhha M H, Nikoonahad Lotfabadi N, Sadeghian Nodoshan F, Morteza Ratki F et al . In Vitro Comparative Study of the Antiproliferative Effects of Liposome- and Niosome-Loaded Curcumin on the A2780 Ovarian Cancer Cell Line. North Khorasan University of Medical Sciences 2026; 18 (2) :26-34
URL: http://journal.nkums.ac.ir/article-1-3382-en.html
URL: http://journal.nkums.ac.ir/article-1-3382-en.html
Mohammad Majdizadeh1 
, Ali-Reza Mofakhamipor-Mehrabadi , Mohammad Hassan Sheikhha1 , Narges Nikoonahad Lotfabadi , Fatemeh Sadeghian Nodoshan1 , Farzaneh Morteza Ratki1 , Bibi Fatemeh Haghiralsadat *2
, Ali-Reza Mofakhamipor-Mehrabadi , Mohammad Hassan Sheikhha1 , Narges Nikoonahad Lotfabadi , Fatemeh Sadeghian Nodoshan1 , Farzaneh Morteza Ratki1 , Bibi Fatemeh Haghiralsadat *2
1- Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ,fhaghirosadat@gmail.com
2- Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ,
Abstract: (34 Views)
Introduction: Conventional cancer treatments are often associated with side effects that reduce patients’ quality of life. Therefore, the development of novel drug delivery systems to achieve targeted therapy and minimize adverse effects is essential. Given advances in nanotechnology, this study aimed to prepare liposomal and niosomal formulations containing curcumin and to evaluate their antiproliferative effects on the A2780 ovarian cancer cell line.
Methods: Four liposomal and four niosomal formulations were prepared using cholesterol, phosphatidylcholine, and Span 60. Physicochemical properties, including particle size, zeta potential, polydispersity index (PDI), drug-loading efficiency, and drug-release profile, were evaluated. Based on these parameters, the optimal liposomal and niosomal formulations were selected. Drug release over 48 hours under conditions simulating healthy and cancerous cells, as well as the cytotoxic effects on the A2780 ovarian cancer cell line, were assessed and compared with free curcumin.
Results: For the selected liposomal formulation, the drug-loading efficiency, particle size, PDI, and zeta potential were 76.63%, 129.79 nm, 0.246, and –18.11 mV, respectively. For the selected niosomal formulation, the corresponding values were 83.66%, 145.62 nm, 0.256, and –25.8 mV, respectively. Drug release from both formulations was slow and sustained. The selected niosomal formulation exhibited greater antiproliferative effects on ovarian cancer cells, with IC₅₀ values of 90.32, 81.25, and 70.37 µg/mL for free curcumin, liposomal curcumin, and niosomal curcumin, respectively.
Conclusions: The developed niosomal formulation demonstrated desirable physicochemical characteristics and higher cytotoxicity against ovarian cancer cells, suggesting it as a promising candidate for further studies in ovarian cancer therapy.
Methods: Four liposomal and four niosomal formulations were prepared using cholesterol, phosphatidylcholine, and Span 60. Physicochemical properties, including particle size, zeta potential, polydispersity index (PDI), drug-loading efficiency, and drug-release profile, were evaluated. Based on these parameters, the optimal liposomal and niosomal formulations were selected. Drug release over 48 hours under conditions simulating healthy and cancerous cells, as well as the cytotoxic effects on the A2780 ovarian cancer cell line, were assessed and compared with free curcumin.
Results: For the selected liposomal formulation, the drug-loading efficiency, particle size, PDI, and zeta potential were 76.63%, 129.79 nm, 0.246, and –18.11 mV, respectively. For the selected niosomal formulation, the corresponding values were 83.66%, 145.62 nm, 0.256, and –25.8 mV, respectively. Drug release from both formulations was slow and sustained. The selected niosomal formulation exhibited greater antiproliferative effects on ovarian cancer cells, with IC₅₀ values of 90.32, 81.25, and 70.37 µg/mL for free curcumin, liposomal curcumin, and niosomal curcumin, respectively.
Conclusions: The developed niosomal formulation demonstrated desirable physicochemical characteristics and higher cytotoxicity against ovarian cancer cells, suggesting it as a promising candidate for further studies in ovarian cancer therapy.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/07/21 | Accepted: 2026/02/2 | Published: 2026/07/1
Received: 2025/07/21 | Accepted: 2026/02/2 | Published: 2026/07/1
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