Abstract Background & Objectives: Bipolar disorder is one of the major mental disease and important cause for to confined (hospitalization).As necessary to gain information about methods treatment for obtain treatment and prevention relapse in particular cognitive behavior therapy group with different techniques Material & Methods: This research is a descriptive and analytic study that is experimental with pretest and post-test and control group . samples according to the clinical and diagnostic interview partially structured for DSM-IV Axis I had a clinical diagnosis of manic depressive psychosis . (N:61) The patients selected by high score in mania and depression scale . the experimental group received 10 treatment sessions. the group were under the drug therapy. The post-test performed after therapeutic intervention, data analysis was by SPSS , 20soft ware. Result : out comes have indicated that after intervention significantly differed between experimental and control groups .(p-value <0.05) Conclusions : Cognitive – behavior therapy group with Role- playing in treatment of Mania and Depression (BMD) is effective.
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